3dasl技术的研究进展及临床应用.pdfVIP

： 国际医学放射学杂志Ｉｎｔ Ｊ Ｍｅｄ Ｒａｄｉｏｌ ２０ 15 Jan鸦 ３8穴1雪 50-53 放射技术学 3D-ASL 技术的研究进展及临床应用 马 进 张 翱* 【摘要】 动脉自旋标记（ASL ）技术是一种内源性对比剂的功能 MRI （fMRI ）技术，由于利用脉冲标记的动脉血 水质子作为内源性对比剂，使其具备无创、成本低、操作简单、可重复检查等优点，有效避免了外源性对比剂所带 来的潜在风险。 3D-ASL 是基于快速自旋回波（FSE ）的螺旋 K （spiral K ）空间采集，能有效克服平面回波成像（EPI ） 所带来的运动伪影和磁敏感伪影。 与常规 ASL 相比，其主要优势包括成像范围更广，影像质量更好，采集速度更 快，信号定位更精准等，故较常规 ASL 应用范围更广，现就 3D-ASL 技术的研究进展及临床应用予以综述。 【关键词】 三维动脉自旋标记；功能磁共振成像；脑血流量；动态磁敏感对比增强；阿尔茨海默病 DOI ：10.3874/j.issn.1674-1897.2015.01.Z0111 The research progress and clinical application of three-dimensional arterial spin labeling MA Jin, ZHANG Ao. Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Yongchuan 402160, China 【Abstract 】 Arterial spin labeling (ASL) utilizing the water in arteries as an endogenous contrast media is a functional magnetic resonance imaging with advantages of noninvasive, lower cost, simpler operation and repetition, and avoiding the potential side effects from exogenous contrast agents. Three-dimensional arterial spin labeling (3D-ASL) which is based on fast spin echo (FSE) spiral K space gathering can effectively overcome motion artifacts and magnetic susceptibility artifacts come from EPI. Compared with the conventional ASL, the main advantages of ASL are more wider image, better quality, faster gathering speed, more accurate signal location and so on. All of the mentioned advantages make it wider application than conventional ASL. The research progress and clinical application of 3D-ASL were reviewed. 【Key words 】 Three-dimensional arterial spin labeling; Functional magnetic resonance imaging; Cerebral blood flow; Dynamic susceptibility contrast; Alzheimer ’s disease