冠心病的综合治疗.pptVIP

Reference: 1. Data on file, Sanofi-Synthélabo 1999, internal report PDY 3494. A loading dose of clopidogrel provides rapid and full effect by 3 hours and was very well tolerated. A study of healthy volunteers demonstrated that the rapid inhibition of platelet aggregation was achieved with a 300 mg dose of clopidogrel alone. The full antiplatelet affect (ADP platelet inhibition between 60–80%) was achieved within 3 hours and a significant effect was seen within the first 1.5 hours.* *At 24 hours, both groups received a second dose of 75 mg An ex vivo model of collagen-induced platelet