Merkel细胞癌的临床影像特征及病理基础.pdf

1904 2010 6 16 12M edicalRecap itulate, Jun 2010, V o.l 16, No. 12 M erkel () 1 2 3 4 张书田 , 张 丹, 李美芳 , 邢传平 ( 1. , 050082; 2. , 401331; 3. , 050014; 4. , 730050) : R739. 4 : A :( 2010) : 总结M erkel细胞癌的临床影像及病理特征 对 64 例M erk el细胞癌患 2 者的临床病史影像表现肿瘤组织的病理形态和免疫组 表达进行回顾性分析 肿瘤 2. 1 常见于头颈部及四肢, 易局部复发并转移病理特点为电镜下瘤细胞胞质内含大量带膜神经 2. 1. 1 64 内分泌颗粒, 角蛋白神经烯醇 酶嗜铬素和突触素阳性CT 和 MR I上可见异常增强的占位 病变, 边界清晰本病预后较差 M erkel细胞癌临床上罕见, 主要靠病理诊断 3 : M erkel细胞癌; 神经内分泌癌; 皮肤肿瘤; CT; 碰共振成像; 影像诊断学; 病理学 , 2 , The Cl inical and Im aging F eature of M erkel C el l Carcinom a and Its Pa thologic B as is( Analysis 1, 1 1 2 3 4 of Ca ses) ZHAN G Shutian , ZHAN Dan , L IM e if ang , X IN G Chuanp ing . ( 1. Departm ent of R a 2. 1. 2 64 d iolog , Bethune InternationalP eaceH osp ita l of PLA, S hij iazhuang 050082, Ch ina; 2. Dep arm ent of L a borator , Chong qing M ed ica l Un iversit , Chongqing 401331, Ch ina; 3. D ep arm ent of L aborator , the , 1; 5 F ourth H osp ita l of S hij iazhuang, Sh ij iazhuang 050014, Ch ina; 4. Lanzh ouM ilitar R eg ion Genera lH os p ita l of PLA, L anzhou 730050, China) , 5 Abstract: O b ectiv e To stud th e clin icopatholog and mi aging features of M erkel cell carcino , 11 m a. M ethods W ith review of the clin ical h istor , mi aging feature, h istopatho log ical changes and mi m unoh istochem ical expressionw ere investigated in 64 cases of M erkel cell carcinom a. Resu lts The 33, 1 h ead and neck are th em ost common site for th is carcinom a. It has an obviou s tendenc of local recur ren ce and m etastasis. There w ere num erousm em brane bounded electro