盐酸缬更昔洛韦片使用说明书 - 核准日期2006课件.pdfVIP

2006 10 2007 02 2010 08 2010 11 ®® Valganciclovir Hydrochloride Tablets Yan Suan Xie Geng Xi Luo Wei Pian 1.L-,-2[(2--1,6--6--9H--9-) ]-3-- 2.9-[[2--1- ] ]L- O H N OH NH2 N O N . HCl N O H2N O C H N O · HCl 12 22 6 5 390.83 AIDS CMV CMV 450mg ( ) Page 1 of 15 10 CMV CMV 900mg 450mg 21 CMV CMV 900mg 450mg CMV 900mg 450mg 10 200 900mg 450mg 10 100 1 CrCl (ml/min) / ≥ 60 900 mg 2 900mg 1 40-59 450 mg 2 450 mg 1 25-39 450 mg 1 450 mg 2 1 10-24 450 mg 2 1 450 mg 2 10 [ ] (140− ) × ([kg ]) = (72) × (0.011× [μmol / l]) =0.85 × (CrCl 10 ml/min) Page 2 of 15 () 500/μl25,000/μl, 8 g/dl AIDS CMV 79 28 21 7