神经炎症在2型糖尿病脑病发病机制中作用研究进展.PDF

·470 · 现代药物与临床 Drugs Clinic 第 30 卷 第 4 期 2015 年 4 月 • 综 述 • 神经炎症在 2 型糖尿病脑病发病机制中作用的研究进展 * * 王 婧，庄朋伟 ，张艳军 天津中医药大学 天津市中药药理重点实验室，天津 300193 摘 要：2 型糖尿病患病人数呈现快速增加的趋势，由其引发的认知功能障碍成为被关注的热点，但其发病机制尚不完全清 楚。近年来一种 2 型糖尿病的“炎症学说”逐渐被越来越多的学者所提及，并且越来越多的研究发现某些因素能够介导神经 炎症从而引发 2 型糖尿病脑病，将从小胶质细胞活化、外周细胞因子、晚期糖基化终产物（AGEs ）与β淀粉样肽（Aβ）等 方面对 2 型糖尿病脑病的引发进行综述，为其治疗药物的开发提供参考。 关键词：2 型糖尿病脑病；神经炎症；小胶质细胞；外周细胞因子；晚期糖基化终产物（AGEs ）；β淀粉样肽（Aβ） 中图分类号：R977 文献标志码：A 文章编号：1674 - 5515(2015)04 - 0470 - 05 DOI: 10.7501/j.issn.1674-5515.2015.04.027 Research progress on role of neuroinflammation in pathogenesis of type 2 diabetic encephalopathy WANG Jing, ZHUANG Peng-wei, ZHANG Yan-jun Tianjin Key Laboratory of Pharmacology of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: The number of patients with type 2 diabetes mellitus (T2DM) shows a rapid increasing trend, and the cognitive dysfunction which is caused by T2DM has been a hot spot of attention, but its pathogenesis are still not entirely clear. In recent years, “the inflammation hypothesis of T2DM” has been mentioned by many researchers, and more and more researches had found that neuroinflammation could act as a trigger for type 2 diabetic encephalopathy (T2DE) which could be mediated by some factors. This review summarizes the factors which could mediate neuroinflammation causing T2DE, including the activation of microglial cells, periphery cytokines, advanced glycation end products (AGEs), β amyloid peptide, and so on, in order to provide reference for the development of treatment drugs. Key words: type 2 diabetic encephalopathy; neuroinflammation; microglia; periphery cytokine; advanced glycation end products (AGEs); β amyloid peptide (Aβ) 随着人们生活水平的提高、生活方式的改变以