miRNA通过细胞周期调控肿瘤形成的机制.pdfVIP

110 ( ) 2010 50 12 Journal of Nanchang University( Medical Science) 2010, Vol. 50 No. 12 miRNA a b ( ) , ( ) ( 辽宁医学院a. 研究生学院2008 级; b. 附属第一医院泌尿外科, 辽宁锦州121001) : miRNAs; ; ; ; ; : R7 : A : 1000- 2294( 2010) 12- 0110- 0 miRNAs( microRNAs, RNA) U TR IL8, cyclin [ ] RNA D1, 8 miRNA19 b Malme , M 50% cyclin D1 mR NA miRNA , 19 b cyclin D 1 mRNA [ 4] cyclin D 1 cyclin E1 miRNA161 ; , , , , 2 cyclin E1 [ 5] miRN As 0% [ 1] 2 miRNAs CDK , miRNA miR NA s cyclin/ CDK( / ) PI K CDK , ( ) Cip/ Kip 9 , , CDK IN K4a/ ARF , cyclinCDK CDK ( CDI) , , CDK 1 miRNAs ( cyclin) miRNAs CDK2CDK4 CDK6, cyclin , miRNA16 ( cyclin dependent ki CDK 1 CDK2 [ 6] nase, CDK , cy miRNA1 7 CDK6, [ 7] clinCDK cyclin miRNA1 7 cyclin D cyclin ED cyclin NSCLC( G0/ G1 , G1 ) Kras CDK4 , G1/ S cyclin E G1 Kras CDK4 CDK4 S CDK2 G1/ S [ 8] , miRNA296 , , [ 2] m