血小板功能异常和缺血性脑血管病.pdfVIP

凰生匡兰堕鱼萱疸瘟壁盟垫堕皇』』笠』盔苤必 ·779 ·综述· 血小板功能异常与缺血性脑血管病 张长春，张颖冬 摘要大量研究表明，血小板功能异常在缺血性脯血管病的发病机制中扮演着相当重要的角色。血 小板黏附和聚集试验能检测血小板的黏附性和聚集性，缺血性脑血管病患者血浆B一血小板球蛋白、 血小板第4冈f、血栓素B2、6一酮．前列腺素F1d、血小板活化因子和P一选择素水平可反映血小板是否 处于活化状态。检测各种血小板功能标志物，有助于了解血小板的功能状念，对缺血性脑血管病的诊 断、预防、治疗和预后判断均有重要意义。 关键词缺血性脑血管病；血小板；发病机制 Platelet andIschemicCerebrov狐cular Dysftmclion Diseases Chang-ChunZhang,Ying—DongZtmg BmH to Medical DepartmentofNew,ologyHospitalAffiliatedNanjing Universi～Nanjing 210029．China have that AlmtmetA numberofstudies great suggestedplateletdysfunctionplays趾important and roleiilthe ofischemiccerebrovascul盯diseases1he adlesion lⅪIaaogenesis platelet aggre· testsc龇detect1tsadihesiveness砌cohesivenessPlasrm gation B—thromboglobulin,platelet factor P—selectinlevelsln 4．thromboxane factor，and 132，6一keto—PGFl“，platelet—activating pa- tientswithischemiccerebrovasculardisensereflectwhether islnanactivestate may platelet nE funclionis toundcrstandthefunctionalsta- detenninationofthemarkers ofplatelet helpful tos lthas inthe of important mad platelet．and significancediagnosis．prevemion．treatmentpre— diseases dictionof forlschemiccerebrOVdSCular prognosis ischemic Key、№I墙 cerebrovasculIlldisease■platelet■pathogenesis dis— Willebrand