磷脂酶D及病原微生物感染.PDF

微生物学通报 NOV 20, 2008, 35(11): 1802~1805 Microbiology © 2008 by Institute of Microbiology, CAS tongbao@ 专论与综述 磷脂酶D 与病原微生物感染 * * 李 帅 韩雪琳 于仁涛 孙岩松 韩 黎 ( 100071) 摘 要: 磷脂酶D(phospholipase D, PLD)普遍存在于细菌、真菌以及哺乳动物中。在病原微生物 中, PLD 作为毒力决定因子在减数分裂、孢子形成等过程中起作用; 在哺乳动物细胞中, PLD 主要 在胞膜转运、调节有丝分裂和细胞肌动蛋白骨架等一些信号转导中起作用。在病原菌感染宿主细 胞的过程中, 病原体和宿主细胞的PLD 都被激活并发生级联反应, 病原菌PLD 可调节自身肌动蛋 白丝的聚合和重排, 并引起宿主细胞局部肌动蛋白丝的集聚, 诱导宿主细胞对其吞噬。深入探讨 PLD 激活对感染发生的调控作用对透彻理解病原菌感染宿主细胞的分子机制具有重要意义。 关键词: 磷脂酶D, 信号转导, 病原微生物 Phospholipase D and Pathogenic Microorganisms Invasion * * LI Shuai HAN Xue-Lin YU Ren-Tao SUN Yan-Song HAN Li (Center for Hospital Infection Supervision, Institute of Disease Control and Prevention, Academy of Military Medical Sciences , Beijing 100071) Abstract: Phospholipase D (PLD) is ubiquitous in bacteria, fungi, and mammal. In pathogenic microorgan- isms, PLD can be pathogenic determinant and play a role in spore generation. In mammalian cells, PLD functions in several signal transduction pathways, such as membrane transportation, mitosis regulation, and actin cytoskeleton regulation. In the process of pathogens invasion host cells, both of the pathogen and host cells’ PLD will be activated and a series of cascade reaction will be generated. During this process, patho- gen’s PLD can regulate the polymerization and reorganization of its own actin filaments and induce