硫化氢对神经退行性疾病保护作用研究进展.PDF

国际病理科学与临床杂志 2013, 33(1) 82 Int J Path ol Clin Me d DOI:10.3969/j.issn.1673-2588.2013.01.015 /gjblkx/fileup/PDFpdf 硫化氢对神经退行性疾病保护作用的研究进展 李文婷 综述 邹伟 审校 ( 南华大学附属南华医院神经内科，湖南 衡阳 421002) [ 摘　要 ] 硫化氢 (hydrogen sulfide，H S) 一直被认为是一种有毒气体。近年来，越来越多的研究显示 H S 在 2 2 哺乳动物体内可以调节及参与一定范围的生理和病理过程。H2 S 在中枢神经系统中扮演着重要的 角色。H2 S 具有抗氧化应激、抗凋亡以及抗炎的作用，而这些生理学意义对研究防治包括阿尔茨 海默病、帕金森氏病在内的神经退行性疾病有着重要的启示。 [ 关键词 ] 硫化氢；神经退行性疾病；氧化应激；凋亡；神经炎症 Progress in research on protective effect of hydrogen sulfide on neurodegenerative disease LI Wenting, ZOU Wei (Department of Internal Neurology, Affiliated Nanhua Hospital, University of South China, Hengyang Hunan 421002, China) Abstract For hundreds of years, hydrogen sulfide (H2 S) has been considered to be a toxic gas. In recent years, more and more studies have shown that H S in the mammalian body can be adjusted and it involves in a range of 2 physiological and pathological processes. H S plays an important role in the central nervous system. H S 2 2 shows effects of anti-oxidant, anti-apoptosis and anti-inflammation, which might be significant in prevention of neurodegenerative disease, such Alzheime