试验二十二大鼠在体小肠汲取试验（国外英文资料）.docVIP

实验二十二大鼠在体小肠吸收实验（国外英文资料） 【 experimental objective 】 the experimental method for the study of the absorption of rats in the circulation of the intestinal tube pump. The mechanism of the absorption of the drug and the calculation of the absorption rate constant (ka) and the absorption of half-life (t1/2 (a)). 【 experimental principle 】 The method of absorption test of the drug digestion tube is generally divided into the test method, the test method and the test method of the body. In vivo test method is not cut off blood vessels and nerves, drugs through the epithelial cells after being away blood, can avoid the stomach and digestive tube eduction inherent movement of physiological effects, such as the dissolved drug is a kind of good research absorption test method. But this law is limited to dissolving state drugs, and may be misused as a absorption by changes in the concentration of drugs caused by other factors. The main way that the digestive tract absorbs drugs is passive diffusion. After taking the drug, a high concentration of the drug in the stomach fluids passes through the low-concentration cells and spreads in a similar way to the blood. This form of absorption does not consume energy, and it is proportional to the concentration difference between the velocity and the membrane. The rate of transmission of molecular drugs; D for the diffusion coefficient of the drug in the membrane; K for the distribution of the drug in the membrane/aqueous solution; C is the concentration of drugs in the digestive system; Cb is the drug concentration in the blood; H is the thickness of the membrane. So, Dk = P, P is the constant General drug transport body immediately after into the circulatory system, so the drug in absorb part of the circulating fluid concentration is relatively low, compared with the drug concentration in gastric intestinal juice, negligible. If the PS/h = k , the (1) can be simplified to: Type (2) indicates that the drug is at the first stage of the s