失眠症治疗药物研究进展.pdfVIP

Hans Journal of Medicinal Chemistry 药物化学, 2017, 5(1), 1-10 Published Online February 2017 in Hans. /journal/hjmce /10.12677/hjmce.2017.51001 The Development of Therapeutic Drugs for Insomnia 1 2 2 1 3 1,3* Huajun He , Gang Wang , Yajun Liu , Xizhou Shen , Kaiyuan Shao , Wenxiang Hu 1 School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan Hubei 2 Beijing Institute of Information Technology, Beijing 3 Beijing Excalibur Space Military Academy of Medical Sciences, Beijing st th st Received: Feb. 1 , 2017; accepted: Feb. 18 , 2017; published: Feb. 21 , 2017 Abstract The number of patients with insomnia is continually increasing recently which has serious impact on their psychological and physiological health and in result people’s demand for sedative-hyp- notic is growing. In this paper, benzodiazepine which was widely used on clinic has been intro- duced, including its mechanism of action, pharmacokinetics, adverse reactions and development history, what’s more, several kinds of new non-benzodiazepine and our traditional Chinese medi- cine’s function on treating insomnia is introduced. Comprehensive analysis found that the combi- nation of Chinese and Western treatment methods and new hypnotic drugs will become the main development direction of the treatment of insomnia. Keywords Insomnia, Benzodiazepine, Non-Benzodiazepine, Hypnotics, Mechanism 失眠症的治疗药物研究进展 1 2 2 1 3 1,3* 何华军 ，王 刚 ，刘亚军，沈喜洲，邵开元，胡文祥 1武汉工程大学化工与制药学院，湖北 武汉 2北京信息技术研究所，北京 3北京神剑天军医学科学院，北京