固定化牛血清白蛋白吸附材料的制备与其对胆红素的吸附性能.PDFVIP

20 10 3 Vol. 28 No. 3 M arch 2010 Ch inese J ourna l of Chrom atog rap hy 291~ 295 研究论文 DOI: 10. 3724 /SP. J. 1123. 2010. 0029 1 1, 2 1 1* 于志远 , 吴仁安 , 邹汉法 (1. , , , 116023; 2. , 100049) : (BSA) [ oly(GMAco TMPTMA) ], BSA (BIA), 4 87 mg/g, BSA BIABIA BIA - 80 ! 3 1 d , BIA : ; ; ; : O65 8 : A : 100087 13(2010)0 3029105 Preparation of bovine serum album in immobilized adsorbent for specific adsorption of bilirubin 1, 2 1 1* YU Zhiyuan , WU Ren∀ an , ZOU Hanfa ( 1. CAS K ey La bor a tor y o f Sepa r a t on Sc en ce for An a ly t ca l Ch em str y, Na t on a l Chr om a togra ph c R. A. C en ter , Da l an In st tu te o f Ch em ca l Phy s cs, Ch n ese A cadem y of Sc en ces, Da l an 116 023, Ch n a; 2. G ra du a te Sch oo l o f Ch n ese Acad em y of Sc en ces, B e j n g 100049, Ch n a ) Abstract: Serum bilirubin concentration is greatly elevated in certain diseases such as hy erbil irubinem ia and severe he atitis. Low ering the level of bilirubin is one of the m ajor targets of m any thera ies such as lasma exchange and hemo erfusion. In this study, a bilirubin s ecific adsorbentwas re ared by covalently mi mobilizing bovine serum album in (BSA) onto macro orous oly ( glycidyl methacrylateco trimethylol ro ane trmi ethacrylate) m icros heres. The resulting BSA mi mobilized adsorbent (BIA) demonstrated good erformance in adsor tion of bilirubin w ith an ad