肝细胞癌分子靶向治疗研究进展.ppt

分子靶向药物—激光制导炸弹 主要是针对肿瘤发生、发展过程中的关键大分子，即参与肿瘤发生、发展过程中的细胞信号传导和其他生物学途径的重要靶点,或是通过强力阻止肿瘤血管生成，从而抑制肿瘤细胞的生长、增殖和转移播散，发挥特异性抗肿瘤作用。 * Selection of patients with well preserved liver function (Child–Pugh A) was important to assess the efficacy of the drug inclusion of patients with more advanced liver dysfunction (Child–Pugh B or C) may have masked sorafenib activity due to liver disease-associated deaths. Treatment continued until radiological progression (RECIST) and symptomatic progression, or unacceptable toxicity, or death. Primary endpoints OS measured from date of randomization until date of death fr