roadshow-利拉鲁肽幻灯.pptVIP

* Once-daily liraglutide produces high pharmacological levels of GLP-1 In a study of healthy individuals, repeated exposure to liraglutide doses (1.25–12.5 μg/kg) resulted in a pharmacokinetic profile similar to that observed following a single dose administration (dosing was performed on day 1 and days 5–11), with steady state being reached after three doses. Half-life was 12 hours at end of study in all dose groups. Before steady-state, slight but statistically significant accumulation was observed at doses of 7.5 μg/kg or greater, as indicated by an accumulation index of 1.4–1.5. This gra