肠促胰素及其类似物_培训课件.pptVIP

* DISCUSSION: Dipeptidyl peptidase-4 (DPP-4) Enzyme DPP-4 is a cell surface peptidase that cleaves chemokines and peptide hormones including GLP-1, thereby decreasing levels of bioactive GLP-11 DPP-4 is a principal determinant of the circulating half life of intact bioactive GLP-11 GLP-1 Receptor When activated (by GLP-1 or GLP-1 receptor agonist), imparts multiple glucoregulatory effects2 GLP-1 receptor agonist specifically targets GLP-1 receptors, thereby mimicking the effects of GLP-12 GLP-1 receptor agonist is not degraded by DPP-41 See accompanying Prescribing Information and safety