阿司匹林联合氟西汀对CUMS抑郁模型大鼠行为学的影响及其可能机制.pdfVIP

5.1 阿司匹林联合氟西汀对慢性不可预见性应激抑郁模型(CUMS) 大鼠体重变化的影响··········································································23 5.2 阿司匹林联合氟西汀对 CUMS 抑郁大鼠自主活动次数的影响 ··············································································································24 5.3 阿司匹林联合氟西汀对 CUMS 抑郁大鼠悬尾不动时间的影响 ··············································································································24 5.4 阿司匹林联合氟西汀对 CUMS 抑郁大鼠糖水摄入量的影响 ··25 5.5 阿司匹林联合氟西汀对CUMS 抑郁大鼠空间学习记忆能力的影 响··········································································································26 5.6 阿司匹林联合氟西汀对 CUMS 抑郁大鼠血清细胞因子的影响 ··············································································································29 5.6.1 阿司匹林联合氟西汀对 CUMS 抑郁大鼠血清 IL-6 水平的 影响································································································29 5.6.2 阿司匹林联合氟西汀对 CUMS 抑郁大鼠血清 TNF-α 水平 的影响····························································································29 5.7 阿司匹林联合氟西汀对 CUMS 抑郁大鼠脑内 PKA 神经元数量 的影响··································································································30 5.8 阿司匹林联合氟西汀对 CUMS 抑郁大鼠海马、皮层 PKA 表达 的影响··································································································32 5.8.1 阿司匹林联合氟西汀对 CUMS 抑郁大鼠海马 PKA 表达的 影响································································································32 5.8.2 阿司匹林联合氟西汀对 CUMS 抑郁大鼠皮层 PKA 表达的 影响································································································33 6 讨论········································································································35 6.1 氟西汀（4mg/kg ）联合阿司匹林（10mg/kg ）可以改善 CUMS 抑郁大鼠的行为学，其抗抑郁效应优于氟西汀（4mg/kg ）组。···35 6.2 氟西汀（4mg/kg ）联合阿司匹林（10mg/kg ）可以调节细胞因子 的失衡、脑内 PKA 神经元数量及阳