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正中中缝核注射5,7-二羟色胺对致痫大鼠癫痫发作及学习记忆的影响论文
dynamics of hippocampal release of serotonin (5-HT) and 5-hydroxyindoleacetic acid
(5-HIAA).
Results
1.Success rate and mortality in pilocarpine-induced epilepsy model: after treatment of
5,7-DHT(PILO+5,7-DHT),the success rate and the mortality were all improved.
2.Behavior change:the seizure of the rats cuuld be devided into three phases: acute
period, silent period and chronic period after treatment of PILO. Compared with the
PILO+SE group, the chronic spontaneous seizures’frequency were increase in
PILO+5,7-DHT group(P0.05),while we did not abserve spontaneous seizures in
PILO-SE group.
3.EEG:Acute period:spike-wave or Spike-and-slow-wave complex were
oberved.Silent period:a-wave was accompanied by a few low sharp-waves or
Spike-and-slow-wave complex.Chronic period: sharp-spike-waves,
Spike-and-slow-wave complex and multiple Spike-and-slow-wave complex were
oberved.
4.Morris water maze (MWM) performance: compared with control group,the mean
escape latency was prolonged,the number of crossing target was decreased and the
retention time in target zone was shortened in PILO+SE group(P0.05),but there was
no significant difference between PILO+SE group and PILO+5,7-DHT
group(P0.05).
5.The number of serotonergic neuron in raphe nuclei: compared with the control
group ,the number of serotonergic neuron in raphe nuclei was decrease in status
epilepticus group (PILO+SE) (P0.05).Moreover,it’s extremely decrease in
PILO+5,7-DHT group(P0.01).
6.The content of extracellular 5-HT and 5-HIAA in hippocampus: in PILO+NS group,
there was a great increase of 5-HT a
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