保留青少年恶性肿瘤患者的生育能力-tumor.PDFVIP

肿瘤2013 年10 月第33 卷第10 期　TUM OR Vol. 33, October 2013　　 935 DOI: 10.3781/j .issn.1000-7431.2013.10.016 Copyright© 2013 by TUM OR Review 综述 · 保留青少年恶性肿瘤患者的生育能力 计　垣 重庆市人口和计划生育科学技术研究院，重庆　400020 [摘要]　随着恶性肿瘤诊疗技术的不断进步，青少年恶性肿瘤幸存者的人数也日益增加。目前已证实，烷化剂类 药物和盆腔放疗可影响青春期正常发育，并可能损害患者的生育能力。为保留青少年恶性肿瘤患者的生育能力， 在治疗前可考虑采用卵母细胞冷冻保存、精子冷冻保存、卵巢组织冷冻保存和睾丸组织冷冻保存等方法。 [关键词]　肿瘤；青少年；不育；保留生育功能 [中图分类号]　R730.7 [文献标志码] A [文章编号]　1000-7431 (2013) 10-0935-04 Fertility preservation for adolescent survivors with malignant tumor JI Yuan Chongqing Institute for Population and Family Planning, Chongqing 400020, China [A BST RA CT]　The number of adolescent survivors with malignant tumor is growing rapidly as the progression in diagnosis and treatment. However, many anti-tumor therapeutic methods, especially chemotherapy with alkylating agents and pelvic radiation therapy have been demonstrated to injure normal pubertal development and may lead to permanent infertility, significantly impacting quality of life. Thus, fertility preservation, such as oocyte cryopreservation, sperm cryopreservation, ovarian tissue cryopreservation and testicular tissue cryopreservation, prior to cancer therapy, must be considered to meet the future reproductive demands of adolescent survivors with malignant tumor. [KEY WORDS]　Neoplasms; Adolescent; Infertility; Fertility preservation TUMOR , 2013, 33 (10): 935-938] [ 当前，应用手术、放疗、化疗或综合治疗措施，已可 年中男性恶性肿瘤发病率为11.79/10 万，女性恶性肿瘤发 使30% 以上的恶性肿瘤获得根治，特别是早期发现和早期 病率为11.99/10 万。男性青少年恶性肿瘤发病率最高的前 诊断的患者[1] 。许多青少年的恶性肿瘤获得了治愈，越来 5 位分别是白血病、脑肿瘤、淋巴瘤、骨瘤和鼻咽癌；女 越多