高等有机合成11.pptVIP

Reactions of CarbonNucleophiles with CarbonylCompounds Oct. 30, 2009 * Aluminum amides Aluminum amides Hydrolysis Alkanine solution of H2O2 3.5. Installation and Removal of Protective Groups 3.5.1. Hydroxy-Protecting Groups 3.5.1.1. Acetals as Protective Groups. THP EE MOM and MEM MEM is more stable than THP under acidic aqueous hydrolysis, But less stable than THP and MOM when treated with ZnBr2, TiCl4, (Me)2BBr, MgBr2 and TMSI. SEM SEM can be removed by TBAF, pyridinium floride, HF, MgBr2 3.5.1.2. Ethers as Protective Groups Me, t-Butyl, triphenylmethyl (Tr) Me and Tr can be introduced