miRNA对T细胞分化及功能的调节作用.PDFVIP

生命的化学, 2014, 34(5): 701-707 余婷, 等. miRNA对T细胞分化与功能的调节作用 doi: 10.13488/j.smhx 701 · miRNA对T细胞分化与功能的调节作用 余婷，肖斌* (第三军医大学药学系微生物与生化药学教研室暨国家免疫生物制品工程技术研究中心，重庆 400038) 摘要：miRNA是一类长度为19~24 nt的内源性非编码小分子RNA ，主要通过抑制mRNA 的翻译或使其 miRNA T 降解对靶基因实现转录后水平的调控。 与 细胞的分化及功能密切相关，参与自身免疫性疾 miRNA T 病、感染性疾病、肿瘤等多种病理过程的免疫调控。本文综述了近年来发现的 在 细胞分化与 功能调节中的作用，特别是其在抗感染与抗肿瘤免疫中的作用。 关键词：微RNA；T细胞；抗感染免疫；抗肿瘤免疫 Research progress of miRNA-mediated regulation for T cell differentiation and function YU Ting, XIAO Bin* (National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China) Abstract: microRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs with about 19~24 nucleotides in length, which carry out the post-transtcriptional regulation of the target genes through inhibiting the translation or degradation of mRNAs. MiRNAs are closely related with the differentiation and functions of T cells and participate in the immunoregulation of autoimmune diseases, infectious diseases and tumor. The miRNA-mediated regulation of T cell differentiation and function, especially the role of miRNA in anti-infection immunity and anti-tumor immunity has been reviewed in this paper. Key Words: microRNA; T cell; anti-infection immunity; anti-tumor immunity miRNA是一类长度约为19~24 nt的内源性非编 疫治疗提供新思路。 码小分子RNA ，主要通过结合目的mRNA分子的3′ + 1 miRNA对CD4 T细胞的调节 端非编码区(3′-untranslated region, 3′UT