13 糖尿病鼠烫伤皮肤组织的ammp-2和timp-2变化.pdfVIP

上海第二医科大学学报 Academicloumalof SecondMedical Shahghai Unive”,hy 【文章编号】0258—5898(2004)03—0181—04 ·基础研究- 糖尿病鼠烫伤皮肤组织的aMMP-2和TIMP-2变化 牛轶雯．陆树良，青春，葛奎，戎柳，王敏骏，廖镇江 (上海第二医科^学瑞金医院 卜海市烧伤研究所，上海200025) 化。方鹾建立以STZ诱导的糖屎病大鼠深Ⅱ度烫伤模型，测定烫伤后O、1、3、7、21 d 于止常组(P005)，伤后21TIMP一2明显低于对照组(P(0 尿病组aMMP-2／…IIMP一2比值逐渐下降，自伤后7 d起，显著低于0时相点(P001)。倍静糖尿病者创伤前后皮肤组织中基质 金属蛋白酶及其相关的生物活性物质的平衡均出现异常。 f关键词】糖尿痫；烫伤；创面愈合；基质金属蛋白酶 【中图分类号】R644；R589．1【文献标识码】A ofactivematrix andtissueinhibitorof Change metallOproteinase-2 ase-2inwoundsofdiabeticandnon．diabeticburnedmice NIU Yi-wen，LUShu-liang，QINGChun，GEKui，RONGLiu，WANGMin-jun，LIAO Zhen-jiang Institute SecondMedical (Burn ofShanghai，RuijinHospital．ShanghaiUniversity，Shanghai200025，China) To the Abstract：Objective ofaMMP-2andTIMP-2inthewoundsofdiabeticandⅡon．diabetic investigatechange burnedmice．Me抽odsThe diabeticSD with rats，inflicted10％tissueburnedsur- streptozotocin(STZ)induced face area(TBSA)ofthickness asthemodel．TheconcentrationsofaMMP-2and deeppartial scalding．were adopted TIMP一2wereobserved thefluid ofculturedtissueon byanalyzing samples postburn with ResuIts normal wasmuch iathe diabeticskin wasob． Compared rats，aMMP2 hi}sher uninjured tissue。TIMP2 loweredonPBD21．After theratioofaMMP2toTIMP2WaSina statusinthenormal viously burn删ury steady group in but decreasedthediabetic ConclusionThebalancebetweenMMPsandtheirinhibit