59例复方丹参注射液致过敏反应的文献分析_康健.pdfVIP

中国药物警戒第10卷第12期 2013年12月 December,2013,Vol.10,No.12 中图分类号：R286;R994.11 文献标识码：A 文章编号：1672-8629（2013）12-0744-05 5 9例复方丹参注射液致过敏反应的文献分析 康健（湖北省襄阳市中医院，湖北襄阳441000） 摘要：目的通过对59例复方丹参注射液致过敏反应的文献进行分析，探讨其引起过敏反应的机制和特点，为临床 安全合理用药提供参考。 对 1994年～2013年中国期刊全文数据库文献进行检索，对其中涉及复方丹参注射液 方法 致过敏反应的42篇文献中报道的59例病例报告进行统计与分析。 复方丹参注射液致过敏反应对性别无差 结果 异，以中老年患者为主；过敏反应出现时间最短为用药后2min，最长为连续用药16d后出现，大多集中在药后30min 内发生；过敏反应累及多个系统-器官，临床表现复杂多样，主要有皮肤及附件损害、呼吸系统、胃肠道系统、全身性 损害、神经系统、心血管系统，其中以心血管系统为主，占27.05%；所有病例均发现及时，立即停药，进行对症处理， 治疗和预后良好，未见死亡病例报道。 临床医师与药师应重视复方丹参注射液所致过敏反应的发生，加强临床 结论 监测，以减少不良反应的发生。 关键词：复方丹参注射液；过敏反应；文献分析 L KANG Jian (Traditional Chinese Medicine Hospital of Xiangyang City, Hubei Xiangyang 441000, China) Abstrac：ObjectiveThrough analysing 59 anaphylaxis cases by Compound Danshen Injection to explore the mechanism and characteristics, provide a reference for clinical rational use of drugs. MethodsBy searching literature in Chinese journal full-text database from 1994 to 2013, 59 anaphylaxis literatures of Compound Danshen Injection involving 59 cases, were statistically analyzed. ResultsIn the 59 anaphylaxis cases by Compound Danshen Injection, it had no selection to sex, and anaphylaxis often occurred in aged group. The shortest time was 2 min after administration and the longest time was 16d, and the most was found in 30 minutes after administration; the major clinical manifestations of anaphylaxis involved many systems and organs, and were complex and varied, and the cardiovascular system was the first, followed by respiratory system, gastrointestinal system, systemic damage, nervous system; all cases were found timely, made an immediate withdrawal and symptomatic treatment to get satisfactory outcome, and no cases