基于疾病中医证候分类的中药药效评价研究思路和方法论文.docVIP

　　基于疾病中医证候分类的中药药效评价研究思路和方法论文 吕爱平, 刘学文, 丁晓蓉 【摘要】 中药的临床应用建立在辨证的基础上，因此其药效评价也应该建立在中医证候分类的基础之上。通过药效学实验阐明中药治疗疾病的药效作用特点及其机制，揭示中药作用机制的科学内涵，是中药现代化和国际化的必然要求，也是探索药物作用靶点，指导临床合理用药的关键所在。如何利用成熟疾病动物模型，并明确其证候特征，是中药药效评价载体研究的关键问题。随着生物医学的发展.freelacodynamic evaluation on Chinese herbal medicine is to clarify the characteristics and action mechanisms of Chinese herbal medicine. It is a request for traditional Chinese medicine (TCM) modernization and a key part in clinic to focus on pharmacodynamic evaluation on Chinese herbal medicine. In present, a lot of results on Chinese herb pharmacodynamic evaluation are not satisfied. Meanain reason is that they ignore the TCM basic theory, e differentiation. The clinical application of Chinese herbs must be established in accordance e differentiation, i.e Chinese herb has its o of pharmacodynamic evaluation on Chinese herb is to clarify the Chinese herb action based on TCM syndrome differentiation. 1 Syndrome classification and Chinese herb pharmacodynamic evaluation Syndrome classification is a kind of odel and efficacy basis in TCM［2］. Chinese medicinal formula is the main form in clinical application of Chinese herbs. It is the key factor to set up syndrome differentiation system ula based on syndrome differentiation. The process of syndrome differentiation is to clear up syndrome classification first, and then to establish principle based on syndrome type and to determine the formula based on principle finally. Thereby, the fine therapeutic action of Chinese herb can be displayed［3］. It is a certain request for syndrome differentiation to build “formulasyndrome” correspondence［4］. “Formulasyndrome” correspondence is the premise and basis for inducing Chinese herb efficacy. The highlight is “selecting certain formula based on certain syndrome”［5］. Ignoring syndrome type to evaluate Chinese herb action singlehandedly can not display objectively. Thus the results can not guide the clinical practice. Hence, the clinical application of Chin