头孢他啶连续与间断静脉给药治疗兔铜绿假单胞菌感染肺炎的比较研究论文.docVIP

　　头孢他啶连续与间断静脉给药治疗兔铜绿假单胞菌感染肺炎的比较研究论文 胡秀娟 王琪 佟淑平 王慧玲 王莺燕 王涛 王伟 王岩岩 【摘要】 目的 比较头孢他啶连续与间断静脉给药治疗兔铜绿假单胞菌感染性肺炎的药动/药效学特点、组织渗透性及疗效。方法 采取连续与间断两种方式以高、中、低三种剂量的头孢他啶治疗铜绿假单胞菌感染的新西兰白兔。绘制血及肺泡间质液中头孢他啶的药时曲线，计算T MIC、T 4MIC、AUC、IQ等药效学参数和肺组织渗透率，对比观察各组用药后疗效。结果 连续组的T MIC、T 4MIC值明显高于间断组；间断组的IQ高于连续组；两者的AUC和组织渗透率无明显差异；除间断给药低剂量组外，各组体温恢复情况无明显差异；治疗后连续组肺组织病理改善较间断组改善明显。结论 与间断给药相比，连续静脉滴注的给药方式可得到更为稳定的血及肺组织中药物浓度，疗效更佳。 【关键词】 头孢他啶； 铜绿假单胞菌； 肺炎； 连续给药； 间断给药 ABSTRACT Objectives To evaluate the pharmacokiic/pharmacodynamic characteristic, the peration rates into lung tissues and the curative effects of ceftazidime administered in continuous versus intermittent infusion in a rabbit Pseudomonas aeruginosa pneumonia model. Methods Ceftazidime onas aeruginosa either as continuous infusion (CI) or as intermittent administration (IA) e daily dose of 50 mg/(kg·d), 25 mg/(kg·d) or 15mg/(kg·d) respectively. The concentrations of ceftazidime in both blood and epithelial lining fluid (ELF) ined and the pharmacokiic analysis ents. The parameters including the time above the MIC, 4MIC (T MIC, T 4MIC), the area under the concenrtrationtime curve (AUC) and inhibitory quotient (IQ) e into lung tissus ptoms and physical signs in the course of the treatments, and the lung pathological characters ittent administration. The IQs ittent administration. No statistically significant different AUCs and peration rates ents, and the same result among the six subgroups in the tents for the symptom and physical sign of the rabbits except the IA of 15mg/(kg·d). The pathologic examination demonstraded that the improvment is better inistration than intermittent infusion. Conclusion Continuous administration of ceftazidime is more efficacious pared ittent administration against Pseudomonas aeruginosa due to its better pharmacokiic characteristics both in blood and lung. KEY IC)密切相关。基于这一理论，很多学者提出应用该类抗生素控制感染时应采取连续24h静脉滴注的给药方式.freell的菌悬液。将兔固定在实验台上，麻醉后，环甲膜切开，插入顶端带气囊的支气管插管至右主支气管，注入上述细菌悬液1ml，保持垂直体位5min。 1.3 实验用药及动物的分组给药 静脉用药采用进口头孢他啶(商品名：