强脊I号方治疗肾虚督寒型强直性脊柱炎的临床研究.pdfVIP

摘 要 摘 要 强直性脊柱炎(Ankylosing Sponylitis, AS)是一种不明原因的自身免疫性疾病,主要 侵犯中轴骨骼、外周关节和关节外结构，根据临床观察，其中大多中医辨证为肾虚督寒 型。 目的：探讨强脊 1 号方对中医辨证为肾虚督寒型的 AS 患者的治疗效果，为临床上 采用治疗AS提供新方法及理论依据。 方法：选取符合标准的临床观察对象，并随机分为对照组、治疗组。对照组应用尼 美舒利，柳氮磺胺吡啶；治疗组加用强脊 I 号方给予，连续治疗 3 个月，并于治疗后 1 个月、治疗后3个月之时测定相关指标，并进行统计分析。 结果：自拟强脊1号方能控制AS病情进展，可明显减轻疼痛程度，提高生活质量， 促进AS活动期ESR、CRP降低并接近正常值,有效提高肾虚督寒型AS患者的甲状腺功能， 并可减少药物的毒副作用。 结论：“肾虚督寒”是AS的重要病机因素，强脊1号方联合尼美舒利、柳氮磺胺吡 啶治疗强直性脊柱炎疗效明确可靠，值得临床应用及推广。 关键词 强脊1号方 强直性脊柱炎 中医辨证 肾虚督寒 I Abstract Abstract Ankylosing Spondylitis (AS) which is an inflammatory disease with unknown cause, mainly affects the axial skeleton, peripheral joints and articular structures. Based on clinical observations, most of them is Shen Xu Du Han in terms of TCM. Objective: To discuss the treatment outcome of the QiangJi No.1 Fang to the patients with AS of Shen Xu Du Han in syndrome differentiation of TCM, thus to provide the new treatment methods and theoretical basis. Methods: To select the standard clinical observation objects, and which are randomly divided into 2 groups. The control group adopts the nimesulide, sulfasalazine; while the treatment group is added with the prescription of QiangJi No.1 Fang. They are treated continuously for 3 months, and determinate the related indexes for statistical analysis after a month, 3 months after the treatment. Results: QiangJi No.1 Fang can control the