神经元的分化.pptVIP

大脑皮层的形成 神经细胞的增殖 Neuronal proliferation 神经细胞的迁移 Neuronal migration 神经细胞分化 Neural differentiation 轴突伸展 Axon guidance 突触形成 Synaptogenesis 神经细胞的死亡 Neuronal death 神经细胞的迁移和分化 Neuronal Migration and Proliferation Inside-Out” Gradient of Cerebral Cortex Formation in the Rhesus Monkey 神经元迁移的方式 radial-directed cortical neuronal migration放射状皮层神经细胞迁移 神经细胞迁移的舞蹈表演 Defects in neuronal migration defects in neuronal migration 思考题 1、神经元迁移的形式 2、神经元细胞放射性迁移的两种方式 Major routes of tangential migration.Numbered arrows are superimposed on Fig. 1 to broadly depict the major routes of cell migration in the developing telencephalon. The question mark on arrow (2) indicates that this route is less well characterized than the others. Key to migratory routes: (1) MGE to the dorsal telencephalon (2) CGE to dorsal telencephalon (3) Cortical-striatal boundary to the ventrolateral telencephalon (lateral cortical stream) (4) LGE to the olfactory bulb (rostral migratory stream). Detailed overview of the known and hypothesized routes of tangential cell migration.The embryonic telencephalon is shown in coronal (a, b) and sagittal (c) cutaways to reveal the multiple pathways of migration. Well characterized routes of migration are shown as a solid arrow; less well characterized routes are shown by a dashed arrow. Key to migratory routes: (1) MGE to neocortex and hippocampus (2) MGE to LGE (3) cortical–striatal boundary to ventrolateral telencephalon (lateral cortical stream) (4) LGE to neocortex and hippocampus (5) CGE to dorsal telencephalon (6) LGE to olfactory bulb (rostral migratory stream) (7) Retrobulbar region to marginal zone75, 76. HIP, hippocampus. The arrows point to the tip of the leading process. Initial ventricle-directed; Subsequently towards the pial surface. Two modes of radial migration 放射性迁移的两种方式 Locomotion Movement of the entire cell, including its leading and trailing process, over considerable distance e.g., glial-guided radial movement of neurons Translocation The cell