富马酸酮替芬分散片在健康人体的药动学及生物等效性评价论文.docVIP

　　富马酸酮替芬分散片在健康人体的药动学及生物等效性评价论文 陈晓莉，文爱东，赵磊，王萌，吴寅，李宏力 【关键词】 富马酸酮替芬 【Abstract】 AIM: To investigate the pharmacokiics and bioequivalence of ketotifen fumarate in healthy volunteers. METHODS: A single oral dose of the tested and control ketotifen fumarate ized t concentration of the tined at different time points inistration by liquid chromatographicmass spectrometric. The main pharmacokiics parameters ain pharmacokiics parameters ax: （2.7±1.2） and （3.1±1.4）h, cmax: （407±147）and（389±168）ng/L, t1/2:（5.5±1.6）and（5.7±2.6）h, and AUC:（2900±1043）and（2763±977）ng/(h L). The relative bioavailability of