痛觉调制通路研究现状.pdfVIP

314 26 2001 4 吴国冀 陈正秋 ( 中国中医研究院针灸研究所, 北京100700) 目前研究比较清楚的痛觉调制通路有: 中脑导水管周围灰质( PA G) - 脑头端腹内侧 区( RV M ) - 脊髓背角/ 三叉神经脊束核通路; PA G- 伏核- 杏仁核- 缰核- PA G 回路; 丘脑中央 下核- 腹外侧眶皮层- PA G 通路; 大脑皮层下行抑制通路: 皮层 S - 伏核/ 缰核- 中缝大核 ( N RM) - 脊髓背角通路; 皮层S 区- 运动皮层- 丘脑髓板内核群通路; 皮层 Sm 区- 尾核- 丘 脑束旁核通路; 下丘脑弓状核( A RH ) 痛觉调制通路: A RH - 中缝背核/ 蓝斑/ PAG 通路; A RH- 中 缝背核- 脊髓背角通路; A RH- 垂体前叶中间叶- 丘脑束旁核通路; 边缘系统- 外侧缰核- 中缝 背核/ PAG - N RM/ 蓝斑- 脊髓背角/ 三叉神经脊束核通路; 痛觉调制的易化通路: RV M - 脊髓背 角通路; 大脑皮层S - S 通路 镇痛 通路 研究进展 Progress in Study on Pain Modulation Neural Pathways Wu Guoji, Chen Zhengqiu ( Inst itute of A cup unct ur e, Chi na A cademy of T CM , Beij i ng , 100700 ) In the present paper, we rev ew t he researches on the neural pathways nvolv ng analges a modu- lat on. Up to now , t he clar f ed pa n modulat on pathways are 1) the descend ng nh b tory pathway o- r g nat ng from the bra n stem: per aqueductal gray ( PAG) - rost ral ventromed al medulla( RV M) - sp nal dorsal horn/ nucleus t ractus sp nal s nerv t r gem n ; 2) the mesol b c neuronal loop: PA G- ucle- us accumbens- ucleus amyg dala- habenula- PAG ; 3) t halam c nucleus submed um- vent rolateral or- b t al cort ex - PA G pat hw ay; 4) t he descend ng nh b t ory pathways or g nat ng from t he cerebral cor- t ex: second somat osensory cortex ( S ) - accumbens/ habenula - nucleus raphe m agnu s ( N RM ) - sp nal dorsal horn pat hw ay, S - motor cort ex - thalam c ntralam nar nucle pathway and sensor- mortor area of the cerebral cort ex - caudat e nucleus- parafasc cular nucleus pat hw ay; 5) t he neural pat hw ays em anat ng fr