间充质干细胞在肿瘤靶向递药系统中的应用.pdfVIP

中咽..斜九 f 学报 134 Joumal of China Pharmaceutical University 2016 ,47 (2) : 134 - 139 间充质干细胞在肿瘤靶向递药系统中的应用 赵月葵l ，唐珊珊2 ，张艳峰2 ，宗 莉l* ，金 咒 口 占 (中国药科大学 l 药剂学教研室;2 生命科学与技术学院分子生物学教研室，南京 21∞09) 摘 要 间充质干细胞(mesenchymal stem cells , MSCs )是干细胞家族的重要成员，来源于发育早期的中胚层和外胚层，属于 多能干细胞，由于其具有分化潜力大、增殖能力强、免疫原性低、肿瘤部位趋向性、取材方便、易于工业化和l 备等特征，有可 能成为最具临床应用前景的多能干细胞。本文介绍间充质干细胞的基本特性以及其在肿瘤靶向递药系统中的研究进辰、 临床应用现状，为间充质千细胞在肿瘤靶向递药系统中的进一步研究提供依据。 关键词 间充质干细胞;靶向递送系统;抗肿瘤;应用 中固分类号 R944 文献标志码 A 文章编号 10∞ -5048(2016)02 -0134 -06 doi: 10. 11665/j. issn. 1000 - 5048 引用本文 赵月葵，唐猾獗，张抱峰，等.间充质千细胞在肿瘤靶向递药系统中的应用[1] .中国药科大学学报，2016 ， 47 (2) : 134 -139. Cite this a耐le 面: ZHAO Yuekui ,TANG Shanshan ,ZHANG Yanfeng ,et al. Enginee时mesenchymalstem cells 嗣 targ创ng therapeutic caniers in cancer therapy[J]. J China Pharm UI脚，2016 ， 47 (2) : 134 - 139. Engineered mesenchymal stem cells as targeting therapeutic carriers in cancer therapy 1 2 2 1 ZHAO Yuekui , TANG Shanshan , ZHANG Yanfeng , ZONG Li * , JIN Liang2 • J Department of Pharmaceut时2ωoratory of M伽， ular Biology, School of Li乒协nce and Technology, China Pharmaceutical Univer- sity, Na可iing 21ω09， China Abstract Mesenchymal stem cells (MSCs) were derived from the early development stage of mesoderm and ectoderm and considered as one of the important members of stem cells family. Besides that , MSCs can be isolated easily and dont have a limitation of moral and ethical problems. Moreover , MSCs can be expanded in vitro which make it possible to use in industrial preparation. Moreover , MSCs possess low immunogenicity and has the ability to home to damaged tissues , tumors , and metastases. The