冠心静胶囊治疗稳定型劳力性心绞痛的疗效观察.PDFVIP

·1016 · 现代药物与临床 Drugs Clinic 第 31 卷 第 7 期 2016 年 7 月 冠心静胶囊治疗稳定型劳力性心绞痛的疗效观察 范红娟，李书瑞，康凯宁，王 辉，王 鑫，关连颖，高 颖 邯郸市中心医院 老年病科，河北 邯郸 056001 摘 要：目的 观察冠心静胶囊治疗稳定型劳力性心绞痛的临床疗效。方法 采用随机、双盲单模拟、阳性药平行对照的研 究方法，将 448 例患者随机分为对照组（112 例）和治疗组（336 例），对照组口服参芍胶囊，4 粒/次，2 次/d ，早、晚服用； 口服参芍胶囊模拟剂，4 粒/次，1 次/d ，中午服用；治疗组口服冠心静胶囊，4 粒/次，3 次/d 。两组均连续治疗 4 周。比较两 组患者的心绞痛症状疗效、心电图疗效、Duke 风险评价和硝酸甘油停减率，并对其安全性进行评价。结果 治疗后，对照 组和治疗组心绞痛症状疗效的总有效率分别为 82.14%、89.88%，心电图疗效的总有效率分别为74.11%、80.65%，两组比较差 异均有统计学意义（P ＜0.05 ）。治疗组的Duke 风险率（85.12% ）明显低于对照组（98.21% ），两组比较差异具有统计学意义 （P ＜0.05 ）；对照组和治疗组的硝酸甘油停减率分别为87.80%、98.36%，两组比较差异具有统计学意义（P ＜0.05 ）。两组均未发 生不良事件，一般体检指标均未发现异常。结论 冠心静胶囊对冠心病心绞痛具有良好的疗效，且临床应用安全性良好，具 有一定的临床推广应用价值。 关键词：冠心静胶囊；稳定型劳力性心绞痛；心绞痛症状疗效；心电图疗效；Duke 风险评价；硝酸甘油停减率 中图分类号：R972 文献标志码：A 文章编号：1674 - 5515(2016)07 - 1016 - 04 DOI:10.7501/j.issn.1674-5515.2016.07.021 Clinical observation of Guanxinjing Capsules in treatment of stable exertional angina pectoris FAN Hong-juan, LI Shu-rui, KANG Kai-ning, WANG Hui, WANG Xin, GUAN Lian-ying, GAO Ying Department of Geriatrics, Handan Central Hospital, Handan 056001, China Abstract: Objective To observe the clinical efficacy of Guanxinjing Capsules in treatment of stable exertional angina pectoris. Methods The stratified random, double blind, single dummy, and parallel control of positive drugs method were applied to this study. Patients (448 cases) were randomly divided into control group (112 cases) and treatment group (336 cases). Patients in the control group were po administered with Shenshao Capsules, 4 grains/time, twice daily, in the morning and evening. And they were po administered with simulation of Shenshao Capsules, 4 grains/time, once daily, at noon. Patients in the treatment group were po administered with Guanxinjing Capsules, 4 grains/tim