干扰素释放分析TSPOTTB诊断结核感染临床应用进展指南.PDF

ACTA ACADEM IAE MEDICINAE SIN ICAE TSPOTTB 张丽帆, 刘晓清 , 100730 : : 01065295087, : lui xq_pum h@ yahoo om n : TSPOT TB , 6 kD 10 kD T , , TSPOTTB, , TSPOT TB : ; ; ; ; T SPOTTB; : R39233 : A : 1000503X( 2009) DOI: 103881/ jissn1000503X200904025 Advances in ClinicalApplications of TSPOT TB for Interferongamm a Release Assay in t e Imm unodiagnosis of Tuberculosis ZHANG Lifan, LIU X iaoqing D epartm ent of Infe tious D iseases, PUM C H ospital, CAM S and PUM C, Beijing 100730, China Correspond ing author: LIU X iaoq ing Te:l 01065295087, Em ai:l liuxq_pum h@ yahooom n ABSTRACT: T SPOT TB is an interferongamm a release assay to dete t T ell response to early se re ting antigen target 6 and u lture filtrate prote in 10 peptides by enzym elinked mi munospot assay for tuber u losis diagnosis It is highly sensitive and spe ifi, and w ill not be affe ted by the subje ts mi mune status and Ba il lus Calm etteGuerin va inationTh is assay has been li ensed for in v itro diagnosis in Europe and the United States Its potential ro les in distingu ishing a tive tuber ulosis from latent tuber ulosis infe tion and predi ting a tive tuber ulosis among indiv iduals w ith latent tuber ulosis have been in reasingly studiesT his arti le re views the advan es in the lini al appli ation of TSPOT TB Key words: tuber ulosis mi munology; tuber ulosis diagnosis; a tive tuber ulosis; latent tuber ulo sis; T SPOTTB; interfer ongamm