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Eur Radiol (2010) 20: 2358–2366 DOI 10.1007/s00330-010-1803-x HEAD AND NECK Sotirios Bisdas An exploratory pilot study Oliver Seitz Markus Middendorp into the association between Nicole Chambron-Pinho Theodosios Bisdas microcirculatory parameters derived Thomas J. Vogl by MRI-based pharmacokinetic analysis Renate Hammerstingl Ulrike Ernemann and glucose utilization estimated by PET-CT Martin G. Mack imaging in head and neck cancer Received: 18 November 2009 Abstract Objectives: To examine the between kep and Ktrans (ρ=0.77), Accepted: 17 March 2010 feasibility of deriving quantitative ve and kep (ρ=−0.7), and iAUC and Published online: 5 May 2010 microcirculatory parameters and to ve (ρ=0.53). Significant correlations # European Society of Radiology 2010 investigate the relationship between were observed for SUVmean and ve as vascular and metabolic character- well as iAUC (ρ=0.42 and ρ=0.66, S. Bisdas ()) :U. Ernemann istics of head and neck tumours in respectively). SUVmax was Department of Neuroradiology, vivo, using dynamic contrast- significantly correlated with iAUC Eberhard Karls University Hospital, enhanced (DCE) MRI and fluoro- (ρ=0.69). Conclusions: The Hoppe Seyler Str. 3, 72076, deoxyglucose (FDG) PET imaging. demonstrated relationships between Tübingen, Germany e-mail: Sotirios.Bisdas@med.uni-tuebingen.de Methods: Twenty-seven patients with vascular and metabolic characteristics Tel.: +49-7071-2986510 primary squamous cell carcinom