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李 寅江南大学工业生物技术教育部重点实验室 In this study we aim to characterize GSH accumulation and its role in lactic acid bacteria. Defined starter cultures of L. lactis are of great economic importance in the bulk production of Cheese. As a facultative anaerobe, strains of L. lactis very often encounter a challenge from oxygen and they have evolved several systems, e.g. NADH oxidase/NADH perosidase system, to survive this challenge (6). The glutathione-dependent reduction system is responsible for maintaining the reduced environment and plays an important role against oxidative stress in E. coli and S. cere