新生儿高胆红素血症患儿脑干听觉诱发电位与血清神经元特异性烯醇化酶变化与临床意义.pdf

主冒额生』b叠盘壶!!堑至苤21鲞簋3翅 ·133 -论 著· 新生儿高胆红素血症患儿脑干听觉诱发电位 及血清神经元特异性烯醇化酶变化及临床意义 陈俊孙小丽郭燕刘芳 南京医科大学附属南京儿童医院‘ 【摘要】目的通过对新生儿高胆红素血症患儿脑干听觉诱发电位(BAEP)及血清神经元特 异性烯醇化酶(NSE)检测，评估高胆红素血症对新生儿听神经损伤。方法56例血清胆红素大于 足月儿为对照组，分别进行BAEP、NSE检测。结果高胆组新生儿BAEP的I、Ⅲ、V波绝对潜伏 其神经损伤有较高的敏感性，可作为监测指标。 【关键词】新生儿；高胆红素血症；脑干听觉诱发电位；神经元特异性烯醇化酶 its The ofBAEPandNSEinneonateswith and clinical change hyperbilirubinemiasiI弘墒came． G^豇锄’s CHEN胁，SUNXiao·li，GUOYah，LIU ofPediatrics，月ffa如ted Fang．Department Hospital Medical Nanjing University，Nanjing210008，China Toobservetheinfluenceof ontheauditionofneonates． 【Abstract】ObjiⅪtive hyperbilirubinemia MethodsBrainstemevoked nenron level specificcnolase(NSE)serum auditory potentials(BAEP)and wereusedtoevaluate neonatal neonateswith brain caused damage by hyperbilirubinemia．Fifry一8k 49 full—telTn bilirubin≥220．5 controlled neonates(total hyperbilimbinemia(totalIxmol／L)and studied．ResultsNeonateswith had bilirubin220．5斗m彤L)were hyperbilirubinemiasignificantly latent internallatent wave in I，Ⅲ，V BAEP(P0． prolongedperiod(PL)andperiod(IPL)of raised reaction than incontrol serumlevelof 叭)，and waveV thresholdthOSC