(华盛顿医疗手册培训-抗生素使用).pptVIP

Macrolide Lincosamide SPECIAL CONSIDERATIONS Macrolides and clindamycin are associated with nausea, abdominal cramping, and LFT abnormalities (particularly erythromycin). Liver function profiles should be checked intermittently during extended therapy. Hypersensitivity reactions with prominent skin rash are more common with clindamycin, as is pseudomembranous colitis secondary to Clostridium difficile. Erythromycin and clarithromycin have major drug interactions caused by inhibition of the cytochrome P-450 system. Sulfonamides and Trimethoprim GENERAL PRINCIPLES Sulfadiazine, sulfisoxazole