肌钙蛋白I定量与心肌酶谱联合检测.docVIP

肌钙蛋白I定量与心肌酶谱联合检测 在小儿病毒性心肌炎临床诊治中的价值 赵志强 姚立腾 甘肃省武威市人民医院 733000 【摘要】目的 探讨肌钙蛋白I（TroponinI；cTnI）定量与心肌酶谱联合检测在小儿病毒性心肌炎（Viral myocarditis；VMC）临床诊治中的价值；方法 测定47例VMC患儿和53例健康对照组的血清cTnI、肌酸激酶（Creatine kinase；CK）、肌酸激酶同工酶（Creatine kinase MB；CK-MB）、乳酸脱氢脱酶（Lactate dehydrogenase；LDH）结果，比较结果，绘制cTnI、CK、CK-MB、LDH受试者工作曲线（ROC曲线）；结果 VMC组入院时与对照组cTnI、CK、CK-MB、LDH结果差异有统计学意义（P＜0.01），治疗2周后cTnI结果与对照组比较，差异亦有统计学意义（P＜0.01），CK、CK-MB、LDH结果与对照组比较，差异无统计学意义（P＞0.05）；结论 cTnI定量与心肌酶谱联合检测在小儿VMC诊断中大大提高了准确性，cTnI在治疗效果监测中起了更好的作用，值得临床常规开展。 【关键词】病毒性心肌炎 肌钙蛋白I 心肌酶谱 ROC曲线 Troponin I quantitative and myocardial enzyme joint test in pediatric viral myocarditis clinical diagnosis in the treatment of value Zhao Zhi-qiang Yao Li-teng Peoples Hospital of Gansu Province ,Wuwei 733000 【Abstract】Objective Explore Troponin I quantitative and myocardial enzyme joint test in pediatric viral myocarditis clinical diagnosis in the treatment of value；Methods Determination of 47 pediatric patients viral myocarditis (VMC) children and 53 patients with healthy controls serum cTnI, CK, CK - MB and LDH results, The comparison results, Draw cTnI, CK, CK-MB, LDH receiver operating curve (ROC curve); Results VMC group and control group cTnI, CK, CK-MB, LDH results were significantly (P 0.01), CTnI results after 2 weeks of treatment compared with the control group, there were significant differences (P 0.01), CK, CK-MB, LDH results compared with the control group, no significant difference (P 0.05); Conclusion cTnI quantitative and myocardial enzyme joint test in the pediatric VMC diagnosis can greatly improve the accuracy, cTnI monitoring treatment in vmc played a better role ，worth to often carry out. 【Keywords】Viral myocarditis Troponin I Myocardial enzymes ROC curve 小儿病毒性心肌炎（Viral myocarditis；VMC）是儿童常见的心血管损伤性疾病，因确诊“金标准”心内膜活检具有创伤性和危险性[1]，临床很难常规开展，至今尚无灵敏、特异、准确的单一的诊断和治疗监测指标，临床常通过病史与体征、心电图、心肌酶等综合检查进行诊治[2]，本文通过对VMC组、健康对照组血清肌钙蛋白I与心肌酶谱的监测，阐述心肌肌钙蛋白I（Cardiac troponinI；cTnI）定量检测与心肌酶谱肌酸激酶（Creatine kinase；CK）、肌酸激酶同工酶（Crea