Jaundice(黄疸).pptVIP

Jaundice Definition Accumulation of yellow pigment in the skin and other tissues (Bilirubin) Bilirubin Metabolism Bilirubin formation Transport of bilirubin in plasma Hepatic bilirubin transport Hepatic uptake Conjugation Biliary excretion Enterohepatic circulation UDPGT: Uridine Diphosphate Glucuronyl Transferase UCB: because of its tight albumin binding and lipid solubility, it is not excreted in urine. CB: is less tightly bound to albumin and is water soluble, so it is filtered at the glomerulus and appears in the urine. Pathophysiologic classification of Jaundice Hemolytic Jaundice