新生儿肺损伤和呼吸的治疗.ppt

新生儿肺损伤和呼吸机治疗; Cytokine Ventilator Induced Lung Injury;肺保护性通气策略主要进展;潮气量;潮气量;PEEP;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;上机模式 触发同步;撤机模式 触发同步;触发同步;触发同步;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;RDS;肺保护性通气策略: CPAP;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;CPAP仪;呼吸机供气相气流上升时间延长;肺保护性通气策略: Surfactant;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;肺保护性通气策略;肺保护性通气策略;肺保护性通气策略;;;;;;;;;呼吸治疗技术发展;90年代的北美和欧洲;急性肺损伤-发生机制: 新线索、新见解;呼吸治疗技术应用的困难和对策;胚胎期Embryonic period;A ~ C: 4 weeks D ~ E: 5 weeks F: 6 weeks G: 8 weeks;胎儿肺泡面积增加与肺容量增加成正比;新生儿呼吸参数;新生儿呼吸参数;呼吸机治疗的主要参数设置;Evolution of oxygen requirement in the two forms of CLD;急性肺损伤-病因; 表面活性物质相对缺乏 持续低氧导致肺内小动脉痉挛，肺血流显著下降，通气-灌流失调 物理、化学、生物等因素影响肺巨噬细胞、组织细胞释放促炎症介质 高氧造成组织细胞蛋白过氧化变性和功能改变，诱发炎症和水肿 病原体直接在肺组织细胞繁殖感染，释放毒素侵袭组织细胞 ;慢性肺损伤-病因;Principles of formation of secondary septa;慢性炎症诱发组织细胞金属蛋白酶活跃，纤维化；新型支气管肺发育不良(New BPD) 内源性肺表面活性物质合成障碍 继发性肾上腺皮质功能低下 免疫反应与生长因子调节紊乱 营养与组织修复功能，全身性疾病的一部分 ;主要内容;Embryonic lung development;From week 22 of gestation pulmonary gas exchange becomes theoretically possible;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;A: Normal B: Air flow limitation as seen in BPD;新的临床研究;机械通气的临床目的;人工呼吸机基本结构;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004