“劳倦过度、房室不节”致肾阳虚及补肾阳对小鼠甲状腺轴及睾丸基因表达谱的影响.pdfVIP

3.T here had been a deerease ofhorm one levelofthy roid ax is in sermu in m iee mo del o f k idn ey 一y an g d efieien ey syn drom e，bu t w ith k idn ey 一yan g n ourish in g th eraP y th e serum h o rn lo n e lev e l in erea sed . 4 . E x P re ssio n o f aP oP to sis related g en e B ax in m iee m o d e i grouP w ere h igh er than th at in m iee eo n tro l grou P ，b ut ex P ressio n o f B ax an d F a sL in treatm ent grouP m ice 10 讹 全 than tho se in m iee m o d el g rouP . 5 . 物 0 seatt er P lo ts o f g en e ex P ressio n P ro file w ere drawn w ith m o d el/co ntro l gro uP an d treatm en t八n o d e l gro uP . D iffe ren tia lly ex P re ssed g en es w ere sereen ed ，in elu d in g 2 4 2 5 uP 一regu lated g en e s an d 3 0 8 0 d own 一regu lated g en es in m o d el/eo nrt o l gro 即 ， 9 9 uP 一regu lated g en e s an d 9 6 d own 一regu lated g en es in treatm en 灯m o d e lg ro 即 .T h ere w ere ten g en e s一翻 on g uP 一regu lated g en e s in m o d el/co nrot l grouP b ut d o确 一regu lated in tre at山en 灯m o d el grouP ，an d fifteen g en es am o n g d own 一regu lated g en es in m o d e l/co n tr0 1 gro uP b ut 即 一regu lated in treatm en t加 o d el grouP . T h ese g en es w ere m a in ly related to cellular stru etur e/允n etio n ， m aterial/en erg y m etab o lism ， sign al tran sdu etio 可relay， tran seriP tio 叭 ran slatio n ， P ro liferatio 川d i价 reniiatio n ， ee ll cy c le an d cell aP oP to sis. A bnorm al exPression of testis genes sueh as 以毕39，Jam Z，(〕比20，A rgl and A kal ，10 in m o d eF eontro l grouP wa s m o du lated in treatm en 灯m o delgrouP b y Jin gu ishen q ib o lu s. C o n elu sio n : Th e re su lts in d icate that o v erfatigu e an d sex u a l o v erstra in co u ld low