中国CPH-中国公共卫生.pdfVIP

2007 2 23 2 Chi n J Publ ic Heal th Feb 2007 Vol. 23 N o. 2 93 : 100 1-0580( 2007) 02-0 193-02 : R 3311 1+ 42 : A = + * K 1, 2 1 1 1 袁春华 , 邹飞 , 蔡春青, 吴航宇 : K + ( PM N s) , PM Ns K + P M Ns K+ , , 56 pS, , - 7 pA , PM Ns - 60 mV , , PM Ns 2 K+ , , , K+ : ; K+ ; + Study on electrophysiological properties of K currents in Neutrophils Y UA N Chun-hua, ZO U Fei , CA I chun-qing, et al . School of P ublic H ealth and T op ical M edicine, Southe n Medical Unive sity ( Guangz hou 51515, China) Abstract: Objective T o nvest gate t he k net c proper t es of potass um channel n human neutr oph ls. Methods Plasma membr ane K+ currents w er e stud ed us ng the cell- attached mode of patch - clamp method. Results T w o d st nct K + cur- 生 rents obser ved w as the voltage- dependent K+ curr ent , ts conductance w as about 56pS; the other w as voltage- ndependent , 卫 　　　 共 the ampl tude of current w as about- 7pA. T he channel w as act vated at - 60mV hold ng potent al , w h ch w as t he rest ng membr ane potent al of neurtoph ls. T he open probab l ty decr easd aw ay from th s hold ng potent al . Conclusion T w o d st nct 公 K+ cur rents nclud ng voltage- dependent and voltage- ndependent current are n the human neutroph ls . T her e are close re- 国