前列地尔联合双抗对脑梗死患者血清FIB及认知功能影响.docVIP

前列地尔联合双抗对脑梗死患者血清FIB及认知功能影响 　　[摘要] 目的 探?前列地尔联合双抗治疗对急性脑梗死患者血清FIB及认知功能的影响。 方法 选取我院神经内科2014年4月～2016年2月收治的急性脑梗死患者92例，按随机数字表法分为两组，各46例，对照组予舒血宁注射液联合阿司匹林治疗；研究组予前列地尔联合双抗治疗，采血测定凝血功能、炎症介质以及氧化应激指标，评定MoCA量表、NIHSS以及Barthel评分，同时比较临床疗效及不良反应。 结果 与治疗前比较，两组治疗后MoCA、Barthel评分升高，NIHSS降低，治疗后血清PT、APTT升高，血清D-D、FIB降低，治疗后血清CRP、IL-6、TNF-α含量降低，治疗后血清NO、MDA降低，血清CAT、SOD升高（P0.05）。 结论 前列地尔联合双抗治疗急性脑梗死疗效显著，可改善凝血功能、炎症介质及氧化应激指标，提高认知功能，值得应用 [关键词] 前列地尔；双抗；急性脑梗死；血清FIB；认知功能 [中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701（2017）09-0059-05 Effect of alprostadil combined with double antibody on serum FIB and cognitive function in the patients with cerebral infarction LIU Xiaoling Department of Neurology， Jinhua Peoples Hospital in Zhejiang Province， Jinhua 321000， China [Abstract] Objective To investigate the effect of alprostadil combined with double antibody on the serum FIB and cognitive function in the patients with acute cerebral infarction. Methods A total of 92 patients with acute cerebral infarction who were enrolled in the Department of Neurology in our hospital from April 2014 to February 2016 were selected. According to the method of random number table， the patients were assigned to two groups of 46 patients. The control group was given Shuxuening injection combined with aspirin； the study group was given alprostadil combined with double antibody. Coagulation function， inflammatory mediators and oxidative stress indicators were performed by blood collection test. The MoCA scale， NIHSS and Barthel scores were evaluated， while the clinical efficacy and adverse reactions were compared. Results The MoCA and Barthel scores were increased and NIHSS was decreased after the treatment in the two groups compared with those before the treatment. After treatment， serum PT and APTT were increased， and serum D-D and FIB were decreased. After treatment， serum CRP， IL-6， TNF-α levels were decreased. After treatment， serum NO and MDA were decreased， and serum CAT and SOD were increased （P0.05）. Conclusion