多发性硬化--英文.pptxVIP

Multiple Sclerosis and Currently Available Treatments in the US Michelle Rainka, Pharm.D., CCRP Dent Institute University at Buffalo mrainka@ mmrainka@ Copyright ?: Reproduction of these slides is prohibited without permission of the author;“Multiple”- multiple areas of lost myelin “Sclerosis”- Scarring MS is a chronic autoimmune inflammatory disease Affects Central Nervous System (brain, spinal chord and optic nerves) ;Multiple Sclerosis;Multiple Sclerosis;MS Statistics;Symptoms of MS;Multiple Sclerosis Kurtzke disability status scale 1 No disability minimal neurologic sign 2 Minimal disability - slight weakness or stiffness, mild disturbance of gait or mild visual disturbance 3 Moderate disability - monoparesis (partial or incomplete paralysis affecting one or part of one extremity) mild hemiparesis (slight paralysis affecting one side of body) moderate ataxia, disturbing sensory loss, prominent urinary or eye symptom, or a combination of lesser dysfunction 4 Relatively severe disability, but fully ambulatory without aid, self sufficient and able to be up and about 12 hours a day, does not prevent the ability to work or carry on normal living activities, excluding sexual dysfunction 5 Disability is severe enough to preclude working, maximal motor function involves walking unaided up to 500 meters 6 Needs assistance walking, for example a cane, crutches, or braces 7 Essentially restricted to a wheelchair but able to wheel oneself and enter and leave the chair without assistance 8 Essentially restricted to bed or a chair, retains many self care functions and has effective use of arms 9 Helpless and bedridden 10 Death due to MS - results from respiratory paralysis, coma of uncertain origin, or following repeated or prolonged epileptic seizures;Diagnosing MS;Diagnosis by Poser Criteria? Clinically definite MS 2 attacks and clinical evidence of 2 separate lesions Laboratory supported Definite MS 2 attacks, either clinical or paraclinical evidence of