β-氯乙烯噻烷和不饱和羰基化合物的3+2反应研究.docx

毕业论文论文题目（中文）β-氯乙烯噻烷和不饱和羰基化合物的3+2反应研究 论文题目（外文）Research on the 3 + 2 Reactions of β –Vinyl chloride and Unsaturated Carbonyl Compounds β-氯乙烯噻烷和不饱和羰基化合物的3+2反应研究摘 要不饱和羰基化合物是许多药物分子或机体内生物学活性分子发挥药物活性或生物活性的重要结构。而3+2环化反应是制备不饱和羰基化合物特别是五元环不饱和羰基化合物最为重要的方法，这种反应通常用烯酮和联烯在有机碱催化下进行的一种环化反应，但通常这些大多数反应都不能很好实现区域选择性，使得反应产物出现两种或两种以上。故找出一种合成方法可以很好地实现区域选择合成五元不饱和羰基化合物是个值得的课题。噻烷及其衍生物可以参与许多官能团的转化，在药物合成中很具有价值。现已发现炔类能与2-氯代-1,3-二噻烷化合物可以生成β-氯代-α，β-不饱和-1,3,-二噻烷化合物在氧化剂下通过自由基反应，该产物可以在碱性环境下转化成联烯噻烷，可以发生亲核亲电加成反应。基于区域选择性亲核/亲电两组分环化反应模式，若氯乙烯基二噻烷和α，β-不饱和羰基化合物反应，那会增加3+2环化的范围。基于以上原因，我们在不同当量碱和不同溶剂用β-氯乙烯噻烷衍生物和不饱和羰基化合物在温和条件下可以实现高度区域选择生成取代环戊烯结构衍生物的模式。该反应具有可以得到较好的产率，很好的底物使用范围，以及操作简单等优点。关键词：β-氯乙烯噻烷;不饱和羰基化合物环戊烯酮结构;3+2反应IStudy on 3 + 2 Reaction of β - Vinyl chloride and Unsaturated Carbonyl CompoundsABSTRACTUnsaturated carbonyl compounds are important structures for many drug molecules or in vivo biologically active molecules to play a pharmacological or biological activity. The most important method for the preparation of unsaturated carbonyl compounds, especially the five-membered ring unsaturated carbonyl compounds, is the 3 + 2 cyclization reaction, which is usually carried out by the cyclization reaction of ketene and alkene under the catalysis of an organic base, but usually Most of these reactions do not achieve good regional selectivity, resulting in two or more reaction products. It is worthwhile to find a synthetic method which can be used to synthesize β-unsaturated carbonyl compounds.Thioxane and its derivatives can be involved in the transformation of many functional groups and are valuable in drug synthesis. It has now been found that the alkyne can react with the 2-chloro-1,3-dithiane compound to produce a β-chloride-α, β-unsaturated-1,3-dithiane compound under an oxidizing agent by free radical reaction , The product can be converted to dithiane in alkaline environment, can occur nucleophilic electrophilic addition reaction. Based on the region-selective nucleophilic / electrophili