急性肾功能不全课件.pdfVIP

氯化汞复制家兔急性肾功能不全对血清肌酐、尿肌酐、尿量、 酚红排泄率及肾系数的影响 （急性肾功能不全） 【摘要】目的：通过观察急性肾功能不全对血清肌酐、尿肌酐、尿量及酚红排泄率的影响来探讨急性肾功 能不全的发病机制及机体代谢变化。方法：家兔7 只，随机分为对照组与实验组，对照组采用氯化汞复制 家兔急性肾功能不全模型。检测家兔血清肌酐、尿肌酐、尿量、酚红排泄率，计算肾系数。结果：实验组 血清肌酐、内生肌酐清除率、酚红排泄率、肾系数较对照组差异无统计学意义（P0.05）；实验组尿肌酐含 量显著低于正对照组（P0.05）；每分钟尿量实验组较对照组少且差异非常显著（P0.01）。结论：急性肾功 能不全可引起内生肌酐清除障碍，尿量减少。本次实验误差较大。 【关键词】急性；肾功能衰竭；肌酐 【abstract】 objective: the acute renal insufficiency to observe in serum creatinine, urine creatinine, urine and phenol red excretion rates to explore the influence of acute renal insufficiency of the pathogenesis and the body metabolic changes. Methods: 7, only rabbits were randomly divided into control group and the control group, the chlorinated mercury copy acute renal insufficiency of rabbit model. Detection of rabbit serum creatinine, urine creatinine, urine, phenol red excretion rate, renal coefficient calculation. Results: the serum creatinine, endogenous creatinine clearance, phenol red excretion rate, the coefficient of kidney was statistically significant differences in the control group (P 0.05); The serum creatinine content is significantly below the urine in control group (P 0.05); Every minute a control group of urine the less and the difference is very significant (P 0.01). Conclusions: acute renal insufficiency can cause endogenous creatinine remove obstacles, and reduce the amount of urine. The larger the error. 【key words】 Acute ；Kidney Failure 急性肾衰竭是一种由多种病因引起的 1.2 方法 急性肾损害，可在数小时至数天内使肾单位 1.2.1 急性肾功能不全模型复制 于实 调节功能急剧减退，以致不能维持体液电解 验前24 h，取七只家兔，称重，四只作为实 质平衡和排泄代谢产物，而导致高血钾、代 验组，按0.8～1.0 ml/kg 体重剂量皮下或肌 谢性酸中毒及急性尿毒症综合征，此综合征 肉注射 10 g/L 氯化汞造成急性肾功能不全 临床称为急性肾功能衰竭。肾脏是机体维持 备用；另外三只皮下或肌肉注射等量的生理 内环境稳定的重要器官。本实验将具体探讨 盐水作为对照组。 急性肾功能衰竭对机体代谢的影响及其机