癌症个体化治疗_纪小龙.pdfVIP

2005 12 12 23 　　CH IN J CANC ER PREV T REA T, Decem ber 2005, Vol.12　No.23 ·1833 · 〖综述 ·讲座〗 纪小龙 解放军武警总医院病理科, 北京100039 Indiv idualized t reatment in cancer J I X iao-long Dep artment of Pathology , General Hosp ital of Armed Police Forces, Beij ing 100039, P .R.China 【】　个体化是肿瘤治疗过程中常常 [ABSTRACT] 　T he personal aspects have alw ays been neglected in 被忽视的问题,肿瘤生物学的 个体化特征 the current treatment of cancer.Individuali ed treatment in cancer 决 了肿瘤治疗的 个体化。癌症的 个体 co mes fr om biolo gical hetero geneity of cancer.Personali ed cancer 化特性包括时间个体化、空间 个体化、解 can be co nceptuali ed along sev eral dimensions.Here, the seven di- 剖上的 个体化、结构的 个体化、基因的 个 mensions of time, env ir onment, dissectio n, co nfigur ation, g ene s, 体化、功能的 个体化和人为的 个体化等七 functio n and man-made factor ar e discussed.The formatio n of integ - 个方面。 医学模式整体观念的形成、后基 rity medicine mo de provides the right time and the po st-g eno mic er a 因组时代的到来, 为肿瘤 个体化治疗提供 provides the nece ssary molecular tools for rendering individuali ed 了必要的契机和工具。 因此, 传统的肿瘤 treatment in cancer .T herefor e, traditio nal clinical treatments of 临床治疗手段正在逐渐被以更为准确的 cancer have been r eplaced by the per so nali ed treatments gradually, 以分子标志物辅助诊断为依据,分子信息 which are in accor dance w ith assistant diagnose of molecular bio mar- 指导下的更为安全有效的 个体化治疗所 ker more exactly and under the direction of more safe and effectiv e 取代。 molecular infor matio n. , 2005, 12(23):1833-1836 Chin J Cancer Prev reat, 2005, 12(23):1833-1836 【】　肿瘤/药物疗法;综述文献 [KEYWORDS]　neopla sm/drug therapy;review liter ature 【】　R730.53 　　　【】　A　　　【】　1009-457 1(2005)23-1833-04 　　, 。 , 1　 1 2 。 , , : 。,