第6-3章微生物学(赵立平)pdf.pdfVIP

Lecture 6-3 Microbial Growth Control in vivo Chapter 27 in Brock Biology of Microorganisms School of Life Science and Technology, Shanghai Jiao Tong University III. ANTIMICROBIAL AGENTS USED IN VIVO 体内使用的抗微生物制剂 6.6 Synthetic Antimicrobial Drugs 人工合成的抗微生物药物 Shanghai Jiao Tong University 6.6.1 Growth Factor Analogs: Sulfa Drugs 磺胺类药物 Growth factor analogs: compounds that are structurally similar to the growth factors, but their structural differences prevent them from duplication the function of the natural G. Domagk growth factor in the cell.生长因子类似物: 与生长因子的结构相似,但不具有生长因 子的功能. Shanghai Jiao Tong University The sulfa drugs were the first widely used growth factor analogs to specifically inhibit the growth of bacteria.磺胺类药物 Sulfanilamide is an analog of p-aminobenzoic acid, which is a part of the vitamin folic acid. Sulfanilamide acts by blocking the synthesis of folic acid, a nucleic acid precursor.磺胺是对氨基苯甲酸的类似物, 可阻断叶酸的合成. Sulfanilamide is active in bacteria but not in higher animals,why? Bacteria synthesize their own folic acid, whereas higher animals obtain folic acid from their diet.细菌自己合成叶酸, 而高等动物从饮 食中获取叶酸. Shanghai Jiao Tong University 6.6.2 Other Growth Factor Analogs Isoniazid, a nicotinamide (vitamin) analog, is effective only against Mycobacterium tuberculosis,异 烟肼, 烟碱的类似物,仅作用于结核分支杆菌. Mechanism: interfere with the synthesis of mycobacterial-specific mycolic acid 影响分支杆菌 特异性的分支菌酸合成, Shanghai Jiao Tong University Amino Acid Analogs Nucleic Acid Analogs Shanghai Jiao Tong University 6.6.3 Quinolones 喹诺酮 A class of synthetic antibacterial compounds that interact with