氟达拉滨药理.docVIP

Fludarabine DRUG NAME: Fludarabine SYNONYM(S): 9-B-D-arabinofuranosyl-2-fluoroadenine 5’-monophosphate, FAMP, 1 2,3 1 3 1,3 1 2-fluoro-ara-A Monophosphate, 2-fluoro-ara-AMP, fludarabine phosphate, NSC-312887 COMMON TRADE NAME(S): FLUDARA? CLASSIFICATION: antimetabolite 1 Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Fludarabine phosphate is a synthetic fluorinated analog of the purine nucleoside antiviral agent vidarabine (ara-A).1,4 1 Unlike vidarabine, fludarabine phosphate is resistant to deamina