刺激大鼠内侧额叶前皮质对听皮层神经元频率感受野可塑性调制.pdf

784 Acta Physiologica Sinica , December 25, 2007, 59 (6): 784-790 Research Paper Modulation of frequency receptive field plasticity in rat auditory cortical neurons by electrical stimulation of medial prefrontal cortex YANG Wen-Wei, ZHOU Xiao-Ming, ZHANG Ji-Ping, SUN Xin-De* College of Life Sciences, Research Center for Brain Science, East China Normal University, Shanghai 200062, China Abstract: Using conventional electrophysiological technique, we investigated the effects of stimulating the medial prefrontal cortex (mPFC) on plasticity of frequency receptive field (RF) in auditory cortical (AC) neurons in rats. When the mPFC was electrically stimulated, the RF plasticity of 51 (27.2%) neurons was not affected and that of 137 neurons (72.8%) was either inhibited (71 neurons, 37.7%) or facilitated (66 neurons, 35.1%). The modulation of RF plasticity by the stimulation of mPFC was dependent upon the time interval between acoustic and electrical stimuli. The best interval time that produced optimal modulation (inhibition or facilitation) ranged from 5 to 30 ms. The inhibitory modulation of mPFC prolonged RF shifting time and shortened RF recovery time. Conversely, the facilitatory modulation of mPFC shortened RF shifting time and prolonged RF recovery time. Our results suggest that the mPFC may affect the plasticity of functional activity in AC neurons, and also may participate in the process of auditory learning and memory. Keywords: medial prefrontal cortex; auditory cortex; frequency receptive field; plasticity; rat 电刺激大鼠内侧额叶前皮质对听皮层神经元频率感受野可塑性的调制 杨文伟，周晓明，张季平，孙心德* 华东师范大学生命科学学院脑科学研究中心，上海 200062 摘 要：本文应用常规电生理学技术，研究电刺激大鼠内侧额叶前皮质(medial prefrontal cortex, mPFC)对初级听皮层神经元频 率感受野(receptive field, RF)可塑性的调制。电刺激mPFC ，137 个听皮层神经元(72.8%) RF 可塑性受到影响，其中抑制性调 制71 个神经元(37.7%) ，易化性调制66 个神经元(35.1%) ，其余51 个神