细胞内吞研究进展_范真真.pdf

生命的化学· 492 · , 2014, 34(4): 492-499 《生命的化学》2014年34卷4期 doi: 10.13488/j.smhx述 细胞内吞的研究进展 * 范真真，陈虹 ，黄秉仁 ( 中国医学科学院北京协和医学院基础医学研究所医学分子生物学国家重点实验室，北京 100005) 摘要：细胞外基质的各种分子经细胞膜进入真核细胞是一个复杂的过程。细胞内吞是通过细胞质膜的 变形运动将细胞外物质转运入细胞内的过程。不同的细胞内吞途径需要不同的蛋白质分子参与，引起 不同的信号转导通路。目前认为细胞内吞和膜转运是细胞对其信号转导过程的一种精密的组织安排， 细胞内吞在细胞信号转导，维持机体动态平衡方面起着重要作用。细胞内吞途径通常可以分为网格蛋 白依赖的内吞和非网格蛋白依赖的内吞，其中后者包括陷窝蛋白依赖和非陷窝蛋白依赖的内吞，以及 巨胞饮介导的内吞。本文将就这几种主要细胞内吞途径及与细胞信号转导通路关系的研究进展予以介 绍。 关键词：细胞内吞；网格蛋白；陷窝蛋白；发动蛋白；巨胞饮 Research progress of cell endocytosis FAN Zhenzhen, CHEN Hong*, HUANG Bingren (The National laboratory of Medical Molecular Biology, Department of Biochemistry Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences School of Basic Medicine, Peking Union Medical College, Beijing 100005, China) Abstract: It is a complex process for the movement of multiple extracellular matrix molecules crossing the eukaryotic cell membrane. Endocytosis is such a process, through which extracellular materials can be transported across the membrane. Different endocytosis pathways require the participation of diverse protein factors, which can activate different signaling pathways. Currently, endocytosis and membrane trafficking are considered to be precise and highly organized in cellular signaling transduction system. In addition, endocytosis plays key roles in cellular signaling and homeostasis. In general, endocytosis can be divided into two types: the clathrin-dependent and clathrin-independent endocytosis pathways. The clathrin-independent endocytosis pathways could be subdivided into three categories: caveolin-dependent endocytosis, caveolin-independent endocy