甘露醇的应用(国外英语资料).docVIP

甘露醇的应用(国外英语资料) Mannitol should be used rationally in patients with cerebral hemorrhage -------------------------------------------------------------------------------- Abstract: 2010-5-8 medicine adding time 18:48:18 Chen Xiaodong |163chenxd@163.com Views: 461 With the extensive use of CT and MRI, it is found that the proportion of progressive enlargement of hematoma is higher. The enlargement of hematoma is related to the degree of blood pressure increasing, the function of blood coagulation, the location of bleeding and the form of hematoma. From the rupture of the blood vessel, the bleeding begins until the balance between the pressure in the hematoma and the last part of the breach is a clot which stops bleeding. This process takes about 2~6 hours. It is dangerous to use mannitol during this time. Because hypertonic mannitol will leak into the hematoma, the hematoma will increase the osmotic pressure, exacerbated by enlargement of the hematoma, and may lead to consequences. But it can not be generalized, we should closely observe the dynamic changes of intracranial pressure, according to specific circumstances. Once suspected of active bleeding, mannitol use should be very careful, as long as there is active intracranial hemorrhage, mannitol application is taboo. Therefore, Chinas pharmacopoeia and mannitol drug instructions are marked active cerebral hemorrhage prohibited. The focal zone cerebral edema: mannitol reduced intracranial pressure depends on the integrity of BBB, mannitol can only remove the water in the normal brain tissue, and the lesion of brain tissue did not dehydration, and because the blood-brain barrier damage, mannitol through ruptured blood vessels into the brain lesion area, causing lesions in the formation of brain edema speed, severity. For patients with cerebral ischemia, the ischemic vascular permeability increase, mannitol by intravascular molecular easily into the gap in ischemic cells, at the same time can not be due to mannitol me